Name | Pipsyl chloride |
Synonyms | Pipsyl chloride p-Iodophenylsulfonyl chloride 4-Jodobenzenesulfonylchloride p-Iodobenzenesulfonyl chloride 4-Iodobenzenesulfonyl chloride 4-IODOBENZENE-1-SULFONYL CHLORIDE 4-Iodobenzenesulfonic acid chloride 4-Iodophenylsulfonyl ChloridePipsyl Chloride |
CAS | 98-61-3 |
EINECS | 202-686-9 |
InChI | InChI=1/C6H4ClIO2S/c7-11(9,10)6-3-1-5(8)2-4-6/h1-4H |
Molecular Formula | C6H4ClIO2S |
Molar Mass | 302.52 |
Density | 1.999 (estimate) |
Melting Point | 80-82 °C (lit.) |
Boling Point | 319.1±25.0 °C(Predicted) |
Flash Point | 146.8°C |
Water Solubility | Reacts with water. |
Solubility | ethanol: soluble100mg/mL, clear to slightly hazy, colorless to yellow |
Vapor Presure | 0.000647mmHg at 25°C |
Appearance | Bright brown crystal |
Color | White to beige or orange |
Merck | 14,7486 |
BRN | 2691661 |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Sensitive | Moisture & Light Sensitive |
Refractive Index | 1.639 |
MDL | MFCD00007441 |
Physical and Chemical Properties | Melting Point: 80 - 82 ℃ |
Hazard Symbols | C - Corrosive |
Risk Codes | 34 - Causes burns |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S28A - |
UN IDs | UN 3261 8/PG 2 |
WGK Germany | 3 |
TSCA | Yes |
HS Code | 29049020 |
Hazard Class | 8 |
Packing Group | II |
EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
Application | 4-iodobenzenesulfonyl chloride is an aromatic hydrocarbon derivative, which can be used as a pharmaceutical synthesis intermediate. |
preparation | 4-iodobenzenesulfonyl chloride the preparation is as follows: to be equipped with mechanical stirring, heating Hood, in a dry 5 L three-necked round bottom flask of a water-cooled condenser, the connecting hose of the condenser was charged with 2.5 L of chloroform and chlorosulfonic acid (503g,4.32 mol). The mixture was heated to mild reflux and a solution of iodobenzene (400g; 1.96 mol) in 0.5 L chloroform was added over 1 hour, during which time, the color of the reaction mixture changed from yellow to deep red-purple with the release of HCl. The reaction was heated at reflux for an additional 1 hour. Complete conversion to p-iodobenzenesulfonyl chloride was indicated by GC analysis. The reaction was worked up by pouring the mixture into a 6 L separatory funnel and then discarding the lower layer, which was mostly a mineral acid. The organic layer was neutralized and dried with MgSO 4. Evaporation of the solvent gave 4-iodobenzenesulfonyl chloride as a crude yellow solid; Yield about 593 g (quantitative). If desired, the product can be further purified by distillation under high vacuum. |